| Sat 07-Aug-2021 |
|---|
| 15:00 | Redbridge | 1‑2 | Ilford | |
| 15:00 | Redcar Athletic | 4‑1 | Hemsworth Miners Welfare | |
| 15:00 | Risborough Rangers | 1‑0 | Lydney Town | |
| 15:00 | Roman Glass St George | 2‑1 | Holmer Green | |
| 15:00 | Romulus | 1‑2 | Uttoxeter Town | |
| 15:00 | Rugby Town | 1‑0 | Boldmere St. Michaels | |
| 15:00 | Saltdean United | 4‑0 | Frimley Green | |
| 15:00 | Sawbridgeworth Town | 0‑3 | Cockfosters | |
| 15:00 | Seaham Red Star | 3‑1 | Crook Town | |
| 15:00 | Sheerwater | 0‑2 | Erith Town | |
| 15:00 | Shepton Mallet | 0‑0 | Andover New Street | |
| 15:00 | Sherwood Colliery | 1‑1 | Boston Town | |
| 15:00 | Shildon | 1‑0 | Garforth Town | |
| 15:00 | Shrivenham | 1‑1 | Burnham | |
| 15:00 | Silsden | 0‑4 | Eccleshill United | |
